Top Venture Capital Firms in Boston

Boston is a powerhouse for innovation, particularly in healthcare, AI, and financial services. As a city that blends elite academia with a thriving startup ecosystem, it's no surprise that many leading venture capital firms are headquartered here. These firms fuel entrepreneurship through early and growth-stage investments, strategic guidance, and deep industry connections.

In this article, we spotlight ten standout Boston-based venture capital firms and what sets them apart.

1. ABRY Partners

ABRY Partners, established in 1989, is a seasoned investment firm that blends private equity and venture strategies. Based in Boston, the firm manages over $90 billion in assets, with a focus on sectors like media, business services, and fintech. ABRY’s team, largely homegrown, is known for its long-term partnerships and operational expertise.

The firm typically invests $50–100 million in later-stage ventures, supporting them through strategic exits such as IPOs or acquisitions. ABRY’s strength lies in scaling businesses across North America and Europe with both capital and strategic vision.

2. Fidelity Investments

While widely known for its asset management capabilities, Fidelity Investments also plays a significant role in venture capital. Headquartered in Boston since 1946, the firm has deployed over $8 trillion across various investment strategies, including early-stage funding.

Fidelity backs startups through its corporate VC arms, focusing on fintech, edtech, and enterprise tech. Their reputation for offering financial infrastructure, along with personalized support, makes them a top-tier investor for emerging businesses aiming for scale and stability.

3. Glasswing Ventures

Glasswing Ventures is an early-stage VC firm founded in 2016 with a sharp focus on artificial intelligence and deep tech. The Boston-based firm leverages its proximity to East Coast academic powerhouses to fund cutting-edge startups in enterprise software, security, and intelligent systems.

Glasswing stands out for its hands-on approach, helping founders build teams, acquire customers, and identify strategic opportunities. Their network-first model makes them a go-to investor for AI-driven businesses in their earliest stages.

4. Highland Capital Partners

Highland Capital Partners has been at the heart of Boston’s venture capital scene since 1987. With a portfolio spanning consumer tech, healthcare, and education, Highland takes pride in championing founders through every stage of their journey.

Highland Capital Partners typically invests between $5 million and $10 million in early-stage companies, from Seed through Series B rounds. The firm has supported the growth of notable portfolio companies such as Rent the Runway, Malwarebytes, and ThredUP.

5. MassVentures

MassVentures is one of the oldest venture investors in Massachusetts, founded in 1978 to back early-stage tech with high potential for economic impact. With $37 million in AUM, the firm plays a unique role by funding deep tech and research-driven startups across the Commonwealth.

It offers more than just capital. MassVentures provides grants, mentorship, and an ecosystem of partners that help innovators bring scientific discoveries to market. Their evergreen model reinvests profits back into the local startup scene.

6. Causeway Media Partners

Founded in 2013, Causeway Media Partners brings a sports-centric focus to venture capital. The firm targets companies at the intersection of media, fitness, and entertainment. With deep ties to the NBA and NFL, the team offers insider access and industry credibility that few can match.

Based in Boston, the firm typically backs Series B and Seed companies with investments ranging from $1–5 million. Their relationship-first model has made them a valuable ally to startups building next-generation sports experiences.

7. Polaris Partners

Polaris Partners is a venture capital firm that has funded innovation since 1996, with a focus on healthcare and technology. With $5 billion in assets under management, the Boston-based firm partners with entrepreneurs from Seed through growth stages.

Their investment philosophy is rooted in collaboration, offering both operational support and a founder-friendly culture. Polaris has backed more than 200 companies, including notable names in biotech, edtech, and software.

8. Underscore VC

Underscore VC is a Boston-native venture firm launched in 2024 with a community-driven approach. Instead of just writing a check, Underscore surrounds founders with a "Core Community" of mentors and peers aligned to the startup's mission.

With $283 million under management, they specialize in Seed-stage investments across sectors like software, marketing, and telecom. Underscore’s distinct edge lies in its human-centric model, designed to empower entrepreneurs from idea to IPO.

9. .406 Ventures

.406 Ventures is a Boston-based venture capital firm managing $1.4 billion in assets. The firm backs early-stage technology companies, primarily at the Seed and Series A stages, with a focus on sectors like cybersecurity, digital health, and cloud infrastructure.

The early-stage venture capital firm is known for its selective portfolio strategy, ensuring each company receives personalized support from the entire investment team. The company never invests in competing businesses, preserving full alignment with founders.

With deep operational experience and entrepreneurial roots, .406 delivers more than capital—they serve as a strategic partner to help innovative technology companies grow and scale in large markets.

10. OpenView Venture Partners

Established in 2006, OpenView Venture Partners is a Boston-based venture capital firm focused on expansion-stage investments in B2B software companies. With $2.4 billion in assets under management and offices in New York and Los Angeles, OpenView supports companies that have achieved product-market fit and are ready to scale.

OpenView’s dedicated Expansion Team provides hands-on operational support in areas like product-led growth, sales, marketing, pricing, and talent acquisition.

Now investing out of its $570 million seventh fund, the firm is known for backing some of the most promising software businesses globally, helping them accelerate growth and build enduring companies.

11. Asymmetric Capital Partners

Asymmetric Capital Partners, founded in 2021, is a strategic investor focused on early-stage fintech, healthcare, and enterprise software. Based in Boston, the firm is known for its thematic approach, investing in structural changes across large markets.

Asymmetric emphasizes deep founder alignment and long-term partnerships. They don’t chase trends; instead, they bet on visionaries solving real problems in legacy industries. Their investments span from pre-seed to Series A.

12. Flare Capital Partners

Flare Capital Partners is one of Boston’s top healthcare venture firms, managing nearly $1 billion in assets. The firm is dedicated to solving healthcare’s biggest challenges: expanding access, improving outcomes, and reducing costs.

With over 70 portfolio companies, Flare combines deep sector knowledge with extensive industry connections. From digital health startups to health IT platforms, they support entrepreneurs with strategic guidance, capital, and access to commercial partners.

13. Boston Millennia Partners

Boston Millennia Partners is a Boston-based venture capital firm specializing in private equity financing for high-growth companies in the healthcare and life sciences sectors. With over $700 million in assets under management, the firm brings deep operational and technical expertise to its portfolio companies.

Founded by a team with decades of experience in venture capital, Boston Millennia Partners offers value beyond capital, providing strategic support in areas such as pharmaceutical partnerships, executive recruiting, and regulatory strategy.

The firm’s long-standing track record reflects its commitment to fostering innovation and scaling transformative healthcare and business services ventures.

14. Battery Ventures

Founded in 1983, Battery Ventures is a global investment firm headquartered in Boston, with additional offices in Silicon Valley, San Francisco, New York, London, and Israel. The firm specializes in venture capital and private equity investments across all stages: from seed to growth-stage companies and buyout.

Battery Ventures focuses on backing breakthrough companies in application software, IT infrastructure, industrial technologies, consumer internet, and mobile services.

With over four decades of experience and a portfolio that spans geographies and industries, Battery Ventures has built a reputation for helping category-defining technology companies scale globally.

Let’s Recap

Boston stands out as a thriving hub for venture capital, with firms like Glasswing, Flare, and Highland driving innovation across tech, health, and AI. These firms offer much more than funding; they bring operational support, domain expertise, and networks that help founders succeed.

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